Treatment of osteoporosis in a mouse model of Duchenne muscular dystrophy using black bear parathyroid hormone
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چکیده
...................................................................................................................................... 13 1 4BIntroduction...................................................................................................................... 14 1.1 11BOsteoporosis Background................................................................................. 14 1.2 12BMenopauseand Age-related Osteoporosis ...................................................... 15 1.3 13BDisuse-related Osteoporosis ............................................................................. 16 1.4 14BDuchenne Muscular Dystrophy ........................................................................ 17 32B1.4.1 DMD and Bone ............................................................................................. 18 1.5 15BOsteoporosis Therapies .................................................................................... 20 1.6 16BParathyroid Hormone ....................................................................................... 21 1.6.1 PTH Variations .................................................................................................... 21 1.6.2 Black Bear PTH ................................................................................................... 22 1.7 DMD Models .......................................................................................................... 23 1.7.1 The mdx Mouse ................................................................................................... 24 1.8 DMD and Osteoporosis Treatments ........................................................................ 25 4 5BSpecific Aims and Hypotheses ............................................................................................... 27 2 Chapter 2: Black Bear Parathyroid Hormone has Greater Anabolic Effects on Trabecular Bone in Dystrophin-deficient Mice than in Wild Type Mice0F .......................................... 29 2.
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تاریخ انتشار 2015